Heterogeneity in Multistage Carcinogenesis

12 Nov 2002 ... They saw considerable heterogeneity but reported a mean number of 20 ACF per cm2. If we assume that the colon is ≈130 cm long and ≈10 cm ...

Incorporation of Inter‐individual Heterogeneity …

Carcinogenesis: Manifestation and Mechanisms - … Multistage models of carcinogenesis have proven useful for defining these events in the neoplastic process, and form the cornerstone of current hypotheses of biological mechanisms of carcinogenesis. These models have been used to demonstrate the multistep process of transformation in a variety of organ systems, such as the skin, liver, urinary bladder, lung, kidney, intestine, mammary gland

21 Jul 2008 ... Carcinogenesis is commonly described as a multistage process, in which stem cells are transformed into cancer cells via a series of mutations. The sources of mutations in cancer are diverse and the complexity of those found ... In the context of neoplastic evolution, genetic heterogeneity is not merely a feature of cancer, ... Multistage carcinogenesis and the incidence of human cancer.

Carcinogenesis is commonly described as a multistage process. In a first step, a stem cell is transformed via a series of mutations into an intermediate cell having a growth advantage.